Synthesis of Piperazines. IX
نویسندگان
چکیده
منابع مشابه
Iridium catalysed synthesis of piperazines from diols.
A green and atom-economical method has been developed for the synthesis of piperazines by cyclocondensation of diols and amines in aqueous media in the presence of a catalytic amount of [Cp*IrCl2]2.
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The structure of 1,4-diphenylpiperazine (1) was determined; it crystallized in the orthorhombic space group Pbca, a = 8.6980(7), b = 8.4287(7), c = 17.6359(15), V = 1292.94(19), Z = 4. Three novel N,N0-disubstituted piperazines were synthesized via reductive amination of piperazine or N-diphenylmethylpiperazine. The products were characterized by NMR and X-ray crystallography. 1,4Diphenethylpip...
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Substituted piperazines and morpholines are valuable structural motifs in biologically active compounds, but are not easily prepared by contemporary cross-coupling approaches. In this report, we introduce SnAP reagents for the transformation of aldehydes into N-unprotected piperazines and morpholines. This approach offers simple, mild conditions compatible with aromatic, heteroaromatic, aliphat...
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This paper describes the synthesis of several new series of 1-(2-aryldiazen-1-yl-) 4-arylpiperazines and 1-(2aryldiazen-1-yl-)4-arylalkylpiperazines by using diazonium coupling between arenediazonium ions with the appropriate 1-arylpiperazine or the 1-arylalkylpiperazine. The new compounds have a common thread in that they are isomers of the series of N-(2,3-dimethylphenyl)N’-(aryldiazenyl)-pip...
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We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1958
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.78.4_338